Symbol
Name
ID

Il2
interleukin 2
MGI:96548

Phenotype annotations related to hematopoietic system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating IgG2 level

Defective B cell differentiation

Abnormal bleeding

Hemolytic anemia

Abnormal B cell count

Decreased proportion of CD4-positive helper T cells

T lymphocytopenia

Lymphopenia

Leukopenia

Hemophagocytosis

Leukemia

Acute lymphoblastic leukemia

Superficial thrombophlebitis

Thrombocytopenia

Lymphoma

Hodgkin lymphoma

Non-Hodgkin lymphoma

Elevated erythrocyte sedimentation rate

Hepatosplenomegaly

Disease(s) Associated with IL2

ataxia telangiectasia

autoimmune thrombocytopenic purpura

Behcet's disease

graft-versus-host disease

pancreatic cancer

rheumatoid arthritis

systemic lupus erythematosus

Mouse Phenotypes

increased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

increased T cell proliferation

decreased splenocyte proliferation

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal class switch recombination

increased pro-B cell number

abnormal T-helper 1 cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

anemia

increased susceptibility to autoimmune hemolytic anemia

abnormal bone marrow cell number

low mean erythrocyte cell number

decreased hematocrit

increased mean corpuscular hemoglobin

abnormal lymphocyte cell number

increased germinal center B cell number

increased plasma cell number

increased pre-B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased T-helper 17 cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

increased regulatory T cell number

increased T cell number

increased activated T cell number

increased single-positive T cell number

abnormal lymphocyte morphology

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology

abnormal gamma-delta intraepithelial T cell morphology

abnormal reticulocyte morphology

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

abnormal lymphocyte physiology

increased IgA level

increased IgE level

increased IgG1 level

increased IgG2a level

increased IgG2b level

increased IgG level

impaired natural killer cell mediated cytotoxicity

abnormal CD4-positive, alpha-beta T cell physiology

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

abnormal T cell activation

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Il2^m1/Il2^m1

Il2^tm1Hor/Il2^tm1Hor

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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